Projects

Medical devices for transfusion security

Among the large number of translational research projects of the group, especially in the field of immuno-combined devices, the « transfusion security » program is emblematic of how we design multi-physics medical devices in an integrated manner.

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GaAs biosensor based on acoustic wave transduction

Pathogenic agents such as bacteria are found widely distributed in the environment water and in biological liquid. The detection at low concentration and the quantification of such biological elements is an issue of extremely importance for the human health. The aim of the project is to design a label free highly sensitive and miniaturized GaAs transducers network with specific bio-interfaces to detect molecules of interest at low concentration in liquid.

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Microparticles qualification and quantification


The “label-free” analytical platform we are working on consists of combining mainly Surface Plasmon Resonance (SPR) analysis, Atomic Force Microscopy (AFM) and mass spectrometry (MS) approaches.
The coupling of these technologies is a promising way to perform a correlation between an average measurement at the macroscale of Microparticles biological activity on the chip and the in situ visualization of nanoscale biological events and protein signatures.

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Acoustofluidic interactions for sensing applications


Resonant piezoelectric microsensors are very suitable for label free sensing in liquid. The devices rely on the interaction between acoustic waves propagating within a thin membrane and the liquid. This work lies with two types of modes of vibration: Lamb waves and bulk acoustic waves.

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Membrane protein characterization in microvesicles


A new program of biomolecular engineering has recently started based on expression of proteins in bacterial expression systems and in particular of membrane proteins in the lactic acid bacterium, Lactococcus lactis. We develop new functional and structural characterizations of these type of proteins involved in many vital process and major targets of pharmaceutical drugs on biochips through label-free technologies, Surface Plasmon Resonance (SPR) and Atomic Force Microscopy (AFM).

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