Projects

Medical devices for transfusion security

Among the large number of translational research projects of the group, especially in the field of immuno-combined devices, the « transfusion security » program is emblematic of how we design multi-physics medical devices in an integrated manner.

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GaAs biosensor based on acoustic wave transduction

Pathogenic agents such as bacteria are found widely distributed in the environment water and in biological liquid. The detection at low concentration and the quantification of such biological elements is an issue of extremely importance for the human health. The aim of the project is to design a label free highly sensitive and miniaturized GaAs transducers network with specific bio-interfaces to detect molecules of interest at low concentration in liquid.

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NBA plateform for extracellular vesicles qualification


We have demonstrated in 2017 that Surface Plasmon Resonance is a suitable method for real‐time, label‐free detection and identification of the specific subset of blood‐derived vesicles. By combining biochip approach to other complementary biophysical methods, like Atomic Force Microscopy (AFM) and Mass Spectrometry (MS), it is possible to reach deeper biomolecular characterizations, proteome profilings and structural features of extracellular vesicles.

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Acoustofluidic interactions for sensing applications


Resonant piezoelectric microsensors are very suitable for label free sensing in liquid. The devices rely on the interaction between acoustic waves propagating within a thin membrane and the liquid. This work lies with two types of modes of vibration: Lamb waves and bulk acoustic waves.

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Membrane protein characterization in microvesicles


A new program of biomolecular engineering has recently started based on expression of proteins in bacterial expression systems and in particular of membrane proteins in the lactic acid bacterium, Lactococcus lactis. We develop new functional and structural characterizations of these type of proteins involved in many vital process and major targets of pharmaceutical drugs on biochips through label-free technologies, Surface Plasmon Resonance (SPR) and Atomic Force Microscopy (AFM).

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 The MiMédi Project - Microtechnology for advanced therapy medicinal products

The MiMédi Project - Microtechnology for advanced therapy medicinal products (ATMPs ; http://projects.femto-st.fr/mimedi/; project for 4 years (2017 to 2021) of  13.6 M€ with funding from the European Regional Development Fund (€10 211 026) and BPI France (€584 000)) combines expertise in microtechnology and nanoscience to those in production of such future drugs to streamline and optimize ATMPs manufacturing  with new technical solutions. ATMPs have recently offered new treatments for patients in therapeutic stalemate. However, manufacturing these medicine cells require complex and expensive technologies

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