Our current research activities in the BIND team address a common objective:
Going from fundamental research to the patient through a better understanding of biological phenomena in close collaboration with health actors and using our expertise in bio-interfaces and innovative microsystems for biological fluids analysis and organ-on-chip development.
To address this objective we currently focus our research efforts in five main axes:
- Microsystems for life sciences: clean-room based fabrication and integration of complex analytical systems
- Label-free detection: multi-parameter detection with optimized bio interface using acoustic or optical signals
- Physical chemistry of surface/interface: understanding and control of surface properties for biological interaction
- Characterization of fluids: characterization of biofluids for diagnosis, biological purpose or agrofood process monitoring
- Bio-on-a-chip: development of organ/tumor/tissue on chip for in vitro study of biological response
The group relies on multidisciplinary skills in biochemistry, biology, engineering sciences and on a strong technological expertise embodied by the use of Mimento, a national micro/nanofabrication platform. The strong links with the Besançon Clinical Investigation Centre for Innovative Technology and the Besançon University Hospital (CHUB) are also evidence of the commitment to the needs of actors in the medical and biological world for patients.
Research axes and know-hows
Our research axes can know-hows can be summarized in the following picture.
Microsystems for life science
- Design of microdevices and lab-on-chip
- Multiphysics modelling for microfluidics and sensing
- Multimaterial clean room based microfabrication
- Design of electronic controls & specific instrumentation for automated systems
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| Acoustic sorting of cells | Droplet microfluidics assay and flow simulation |
Label-free detection
- Multiparameter and multiscale label-free detection in flow.
- Acoustic waves and optical high sensitive sensors in complex biological fluids.
- Multiplexed detection with bio-interface optimization for analyzing molecule affinity with specific target
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| Acoustic biosensor assay for in vitro diagnosis | Frequency shift during whole blood perfusion |
Characterization of biofluids
- In solution and on-a-chip studies of biological samples through fluorescent imaging and multiplexed biodetections
- Monitoring & profiling of biomarkers for diagnosis and biological purposes
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| On-chip RBC specific immunocapture | TRPS analysis of bacteria |
Physical chemistry of surface/interface
- Tunable localized reactivity.
- Wide range of robust, sustainable and versatile surface functionalization.
- Deep understanding and control of biointerface engineering.
- Design/elaboration of specific biosensors, self-cleaning surfaces & antimicrobial devices.
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| Functionnalization strategies | Micro pH sensing |
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non treated treated |
| Immunosensors functionnalization | Biofouling on titanium against bacteria… |
Bio-on-a-chip
- Cancer-on-a-chip
- Organoids on chip
- Blood-brain barrier on chip