In the context of nanoscale research development, the Nano2BIO team brings together expertise in analytical sciences, biodetection, and multiphysical and multiscale characterization. They are developing tools and methodologies for multiplex, label-free characterization of biological targets, serving biology and health applications.

Objectives and Scientific Themes

The team addresses scientific challenges such as biodetection and metrological, morphomechanical, and spectral nanoscale characterization of biological entities. They propose multimodal bioanalytical and methodological solutions, focusing on developing strategies for functionalizing organic and inorganic substrates with synthetic and natural ligands. Their goals include detecting biological targets (molecular, vesicular, and cellular) or synthetic compounds under non-ideal conditions. Conversely, Nano2BIO also investigates molecular interactions under ideal conditions and studies correlations between measured signals and trapped molecules, as well as between measured signals and the number/shape/size of trapped objects. Nano2BIO aims to provide multiscale and multiomic qualification of samples to contribute to a better understanding of "composition and function" relationships.


  • Development of micro/nanostructured substrates and strategies for grafting synthetic and natural ligands
  • Determination of kinetic constants and molecular interaction in heterogeneous phases
  • Biodetection of biological targets (molecular, vesicular, and cellular) using surface plasmon resonance, interferometry, and Raman spectroscopy
  • Chemometric analysis of multimodal data for fine discrimination of coexisting subpopulations in a sample


The team's work contributes to national and international recognition in the following domains:

  • Label-free biomolecular interaction analysis
  • Multiplex biochips for in vitro diagnostics and screening
  • Analytical platforms and methodologies for phenotypic, metrological, morphomechanical, and spectral characterization of biological targets in complex environments
  • Raman spectroscopy on nano-trapped objects on biochips for discriminative analysis of subpopulations of interest.