The team

The Nano2BIO team, in October 2025

Permanent members : Céline Elie-Caille, Wilfrid Boireau, Jérome Dejeu, Benjamin Brunel, Alain Rouleau

Contractual members : Eugénie Vidal, Almar Al Assaad

PhD students : Mohamed Kouryani, Doha Zorkot



Céline Élie-Caille

Associate Professor – University of Franche-Comté

Head of the Nano2BIO team

Expertise in Atomic Force Microscopy for the qualification of multi-scale biological objects, from molecules to cells, in Micronanostructuring of substrates, in Purification and reconstitution of membrane proteins in proteoliposomes and supported lipid bilayers.

https://www.femto-st.fr/fr/personnel-femto/celineelie

https://scholar.google.fr/citations?user=UEIrR_MAAAAJ&hl=fr

https://www.linkedin.com/in/celine-elie-caille-296617109/?originalSubdomain=fr

Mail : caille@femto-st.fr

Tel : 0381666607

Wilfrid Boireau

Research Director - CNRS

CLIPP platform Manager

Expertise in supramolecular engineering, functional biointerfaces, biophysical characterization of molecular interactions, qualification of multi-scale biological targets (molecules, extracellular vesicles, cells) in biofluids.

https://www.femto-st.fr/fr/personnel-femto/wilfridboireau

https://scholar.google.com/citations?user=OefjStAAAAAJ&hl=en&oi=ao

https://www.linkedin.com/in/wilfrid-boireau-402102b4/

Mail : wboireau@femto-st.fr

Tel : 0381666607

Jérome Dejeu

Associate Professor – SUPMICROTECH ENSMM

Expertise in surface functionalization, biophysical characterization of molecular interactions (DNA, proteins, sugars, etc.): kinetics and thermodynamics.

https://www.femto-st.fr/fr/personnel-femto/jeromedejeu2

https://www.webofscience.com/wos/author/record/B-5745-2013?state=%7B%7D

https://scholar.google.fr/citations?hl=fr&user=MjY3LeIAAAAJ&view_op=list_works

https://www.linkedin.com/in/j%C3%A9r%C3%B4me-dejeu-862049171/

Mail : jerome.dejeu2@femto-st.fr

Tel : 0363082623

Benjamin Brunel

Associate Professor - ISIFC

Expertise in Raman spectroscopy, focusing on optical aspects (Raman microscopy, SERS) and data analysis (chemometrics, machine learning), applied to the analysis of biological samples (tissue histological sections, cells, EVs).

https://www.femto-st.fr/fr/personnel-femto/benjaminbrunel

https://scholar.google.fr/citations?user=R58AkoAAAAAJ&hl=fr

https://www.linkedin.com/in/benjamin-brunel-755699b2/

Mail : benjamin.brunel@femto-st.fr

Tel : 0363082476

Alain Rouleau

Engineer

Specialized in biology (immunology, physiology, oncology, in vitro diagnostics), works at the FEMTO-ST Institute in Besançon. He participates in projects on bio-interactions (Surface Plasmon Resonance), the development of biological sensors, and optical, biochemical, and biophysical characterization. He is also the technical manager of the CLIPP proteomics platform.

Mail : alain.rouleau@femto-st.fr




Eugénie Vidal

Engineer

Engineer, recruited on ENDOMITOPAH ANR project (2024-2027)

Developing a method for characterization and lysis of extracellular vesicles for subsequent proteomic analysis.

Mail : eugenie.vidal@femto-st.fr

Sylvain Midrouet

Research Engineer

Focusing on replicating coagulation process in microfluidic and biomimetic chips.

Recruited on EV TEST Project in order to characterize sub-populations of EVs using an immunocapture module (FEMTO-ST, Besançon) coupled with a hydrodynamic sorting module (LAAS, Toulouse).

Mail : sylvain.midrouet@femto-st.fr

https://www.linkedin.com/in/sylvain-midrouet-11aa1483/

Almar Al Assaad

Research Engineer

Recruited as a research engineer for the FEDER I-NanoT project, my mission is the comprehensive characterization of various types of therapeutic and theranostic nanovectors. This will be achieved using my core expertise in Raman spectroscopy and data analysis, added to a range of key biophysical techniques such as SPRi, BLI, and AFM.

www.linkedin.com/in/almar-al-assaad

https://cv.hal.science/almar-al-assaad

Mohamed Kouryani

2nd year PhD

PhD student (2nd year)
Development of a Biochip compatible with surface-enhanced Raman spectroscopy (SERS) and surface plasmon resonance (SPR) for the characterization of extracellular vesicles.
Mail : mohamed.kouryani@femto-st.fr

Doha Zorkot

2nd year PhD

PhD student (2nd year)


Multiscale and dynamic analysis by multiplex nanobiochips of secretomes from macrophages and fibrogenic cells.


Mail : doha.zorkot@femto-st.fr

Fareeha Afzal

Engineer

Studied Master's degree in Biomedical Engineering at the University of
Marie et Louis Pasteur, France. Her expertise lies in machine learning and deep learning for healthcare applications like identifying keloid biomarkers, survivability of thyroid cancer, denoising Raman spectra, NMR blood analysis, as well as analyzing high-dimensional datasets.

In Nano2BIO team, her mission is to analyze high dimensional datasets from Raman spectroscopy of Extracellular vesicles.