The team

Céline Élie-Caille

Associate Professor – University of Franche-Comté

Head of the Nano2BIO team

Expertise in Atomic Force Microscopy for the qualification of multi-scale biological objects, from molecules to cells, in Micronanostructuring of substrates, in Purification and reconstitution of membrane proteins in proteoliposomes and supported lipid bilayers.

Mail :

Tel : 0381666607

Wilfrid Boireau

Research Director - CNRS

CLIPP platform Manager

Expertise in supramolecular engineering, functional biointerfaces, biophysical characterization of molecular interactions, qualification of multi-scale biological targets (molecules, extracellular vesicles, cells) in biofluids.

Mail :

Tel : 0381666607

Jérome Dejeu

Associate Professor – SUPMICROTECH ENSMM

Expertise in surface functionalization, biophysical characterization of molecular interactions (DNA, proteins, sugars, etc.): kinetics and thermodynamics.

Mail :

Tel : 0363082623

Benjamin Brunel

Associate Professor - ISIFC

Expertise in Raman spectroscopy, focusing on optical aspects (Raman microscopy, SERS) and data analysis (chemometrics, machine learning), applied to the analysis of biological samples (tissue histological sections, cells, EVs).

Mail :

Tel : 0363082476

Alain Rouleau

Engineer - University of Franche-Comté

Specialized in biology (immunology, physiology, oncology, in vitro diagnostics), works at the FEMTO-ST Institute in Besançon. He participates in projects on bio-interactions (Surface Plasmon Resonance), the development of biological sensors, and optical, biochemical, and biophysical characterization. He is also the technical manager of the CLIPP proteomics platform.

Mail :

Tel : 03xxxxxxxx

Eugénie Vidal


Master 2 student, (Aix Marseille University / Master in Health Biology with a focus on Health Technologies)

Developing a method for characterization and lysis of extracellular vesicles for subsequent proteomic analysis.

Mail :

Mohamed Kouryani


Master 2 student (University of Picardie Jules Verne / Master's in Materials Science and Engineering - Physics and Engineering of Nanomaterials)
Development of a Biochip compatible with surface-enhanced Raman spectroscopy (SERS) and surface plasmon resonance (SPR) for the characterization of extracellular vesicles.
Mail :

Thiziri XX


Master 2 student

Lia Rifat Jaha


Master2 student (Bourgogne Franche-Comté University / Master's in Internet of Things)
Multimodal nano-analytical approaches for the characterization of extracellular vesicles: data processing.
Mail :

Geetika Raizada

Third-year PhD

Third-year PhD student (Supervisors: Céline Elie Caille, Wilfrid Boireau & Eric Lesniewska), UBFC.
High-speed discriminant analysis of subpopulations of extracellular vesicles (EVs) trapped on a multiplex chip.
Mail :