Dominique Collard and Cagatay Tarhan

LIMMS/CNRS-IIS the University of Tokyo, Japan


Tentative title:

Silicon Nanotweezers for biomolecules and cells manipulations and characterisations



In modern life, technologies enabling detection of biological molecules at a low threshold, for health and ecological concerns, are in high demand. Directly interrogating the molecules is a promising direction to clarify the noisy response of conventional assays arising from simultaneous different reactions. Besides sophisticated biophysical instrument such as the atomic force microscope, this seminar proposes silicon nanotweezers (SNT) as a new microsystem for molecular manipulation. SNT can trap molecules and sense their biomechanical and bioelectrical response in minute operations. In this review SNT characteristics are overviewed; their operation modes are illustrated by molecule and cell trapping, manipulation and characterization in air and in solution. As they are tiny and can be mass produced by highly parallel microsystem technology, SNT can be seen as a potential molecular and cellular probe for routine analysis and bio detection, specially recently for cancer cell identification. 



Dominique Collard was born in Cambrai, France in 1958. He received the Eng. Degree from ISEN (Institut Supérieur d’Electronique et du Numérique) in 1980, and the PhD degree from the University of Lille in 1984. Since 1988, he has been with the Centre National de la Recherche Scientifique (CNRS), being alternatively with the Institut d’Electronique, de Microélectronique et de Nanotechnologie (IEMN), Lille, and with the Laboratory for Integrated MicroMechatronic Systems (LIMMS/CNRS-IIS), Tokyo.  He is authors or co-author of more than 300 international publications. Dominique Collard got the CNRS bronze medal in 1992, and was in 2004 Laureate of the French academic palms from Ministry of higher education and research. In June 2014 he was named as Director the SMMiL-E Project (Seeding Micro System in Medecine in Lille: European-Japanese technologies against Cancer) to pull BioMEMS to Cancer research of Lille, France in a project supported by CNRS, IIS/The University of Tokyo, Lille University, Centre Oscar Lambret. Since April 2016, back in Lille Dominique Collard is in the coordination the CPER Cancer plan that aims gathering research on physics, human science, biology and clinics for Cancer in a unique place inside the Lille University hospital campus.


M. Cagatay Tarhan is an associate professor in the BioMEMS group at the Institute of Electronics, Microelectronics and Nanotechnology (IEMN), Villeneuve d'Ascq, France. He received his B.S. degree in electrical and electronics engineering from Middle East Technical University, Ankara, Turkey in 2003, M.S. and Ph. D. degrees in electrical engineering from The University of Tokyo, Tokyo, Japan in 2007 and 2010, respectively. He worked as a researcher at the Institute of Industrial Science, The University of Tokyo (2010-2014) and at the Laboratory for Integrated MicroMechatronic Systems (LIMMS/CNRS-IIS), Tokyo (2014-2016). Since 2016, he has been in his current position in France. In December 2018, he was named as the director of the SMMiL-E Project (Seeding Micro System in Medicine in Lille: European-Japanese technologies against Cancer), a project supported by CNRS, IIS/The University of Tokyo, Lille University, Centre Oscar Lambret, to apply BioMEMS technology to cancer research in Lille, France.