Our current research activities in the Bio Microdevices group address a common objective:
Going from fundamental research to the patient through a better understanding of biological phenomena in close collaboration with health actors and using our expertise in bio-interfaces and innovative microsystems for biological fluids analysis.
To adress this objective we currently focus our research efforts in four main axes:
- Microsystems for life sciences: clean-room based fabrication and integration of complex analytical systems
- Label-free detection: multi-parameter detection with optimized bio interface using acoustic or optical signals
- Physical chemistry of surface/interface: understanding and control of surface properties for biological interaction
- Characterization of biofluids: micro to nano-scale characterization of biofluids for diagnosis or biological purpose
The group relies on multidisciplinary skills in biochemistry, engineering sciences and on a strong technological expertise embodied by the support of the CLiPP analytical platform and the use of Mimento, a national micro/nanofabrication platform. The strong links with the Besançon Clinical Investigation Centre for Innovative Technology and the Besançon University Hospital (CHUB) are also evidence of the commitment to the needs of actors in the medical and biological world for patients.
Research axes and know-hows
Our research axes can know-hows can be summarized in the following picture.
Microsystems for life science
- Design of microdevices, multimaterial clean room based fabrication.
- Multiphysics modelling for microfluidics and sensing
- Design of electronic controls & specific instrumentation for automated systems.
- Lab-on-chip based on microfluidics for monitoring of various phenomena in different domains of application.
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Acoustic sorting of cells | Droplet microfluidics assay |
Label-free detection
- Multiparameter and multiscale label-free detection in flow.
- Acoustic waves and optical high sensitive sensors in complex biological fluids.
- Multiplexed detection with bio-interface optimization for analyzing molecule affinity with specific targets.
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Sensitivity comparison of different home made SPR Chips | Acoustic biosensor assay for in vitro diagnosis |
Characterization of biofluids
- Analytical challenges on biofluids based on skills dealing with nano to macro scale characterizations
- In solution and on-a-chip studies of biological samples through nano-investigations and multiplexed biodetections
- Monitoring & profiling of biomarkers for diagnosis and biological purposes
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AFM imaging of Extracellular Vesicles from human plasma | Platelet capture on collagen chip from blood patient |
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On-chip RBC specific immunocapture | TRPS analysis of bacteria |
Physical chemistry of surface/interface
- Tunable localized reactivity.
- Wide range of robust, sustainable and versatile surface functionalization.
- Deep understanding and control of biointerface engineering.
- Design/elaboration of specific biosensors, self-cleaning surfaces & antimicrobial devices.
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Functionnalization strategies | Micro pH sensing |
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non treated treated |
Immunosensors functionnalization | Biofouling on titanium against bacteria… |
